Sign of nerves about work issue (5)

From Daily Telegraph Cryptic 31273, 22A

22A — Sign of nerves about work issue (5)TOPIC

  • Definition
    Definition found: 'issue' — The straight definition sits at one end — here it's the single word naming a subject or matter under discussion.
  • Indicator
    Indicator found: 'about'
  • Operation
    'about' signals a container operation
  • Fodder
    Fodder: 'Sign of nerves work'
  • Synonym
    Synonyms spotted: 'Sign of nerves' → TIC
  • Synonym
    Synonyms spotted: 'work' → OP
  • Assembly
    TIC + OP = T(OP)IC

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